About the Cover
Cover Picture: Human-specific compartmental organization of human primary visual cortex (area V1; Brodmann's area 17). Photomicrograph showing the upper bank of the calcarine fissure; the image was rotated to show the cortical layers in conventional orientation. This coronal section was double-immunostained for nonphosphorylated neurofilaments with the SMI-32 antibody (reddish-brown reaction product) and for perineuronal nets with the Cat-301 antibody (blue reaction product). Staining with these antibodies reveals a striking pattern of alternating light- and dark-staining compartments in layer 4A. The dark territories are packed with cells bodies and neuropil that stain with SMI-32 or Cat-301. The light-staining compartments contain numerous small somas that are immunoreactive for calbindin, as demonstrated by other double- immunostaining experiments in this series. Comparative studies of humans, apes and monkeys indicate that this pattern of compartmentation is unique to humans. See Preuss and Coleman, pp. 671–691.
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