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Cerebral Cortex Advance Access originally published online on March 28, 2004
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Cerebral Cortex May 2004; 14:496-502
© Oxford University Press 2004

Article

Identification and Differential Vulnerability of a Neural Network in Sleep Deprivation

Sandra Bell-McGinty*,1,3, Christian Habeck*,1, H. John Hilton1,2,6, Brian Rakitin1, Nikolaos Scarmeas1,2, Eric Zarahn1, Joseph Flynn1, Robert DeLaPaz4, Robert Basner5 and Yaakov Stern1,2,3,6

1 Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, 2 Department of Neurology, 3 Department of Psychiatry, 4 Department of Radiology, 5 Department of Medicine, 6 Department of Psychology, College of Physicians and Surgeons of Columbia University, 630 West 168th Street, New York, USA, *Both authors contributed equally to this manuscript

The study aimed to identify task-related brain activation networks whose change in expression exhibits subject differences as a function of differential susceptibility to sleep deprivation. Brain activity during a non-verbal recognition memory task was investigated in an event-related functional MRI paradigm both prior to and after 48 h of sleep deprivation. Nineteen healthy subjects participated. Regional covariance analysis was applied to data. An activation network pattern was identified whose expression decreased from pre- to post-sleep deprivation in 15 out 19 subjects (P < 0.05). Differential decrease in expression correlated with worsening performance in recognition accuracy (P < 0.05). Sites of de-activation were found in the posterior cerebellum, right fusiform gyrus and precuneus, and left lingual and inferior temporal gyri; increased activation was found in the bilateral insula, claustrum and right putamen. A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation.


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B. Luber, A. D. Stanford, P. Bulow, T. Nguyen, B. C. Rakitin, C. Habeck, R. Basner, Y. Stern, and S. H. Lisanby
Remediation of Sleep-Deprivation-Induced Working Memory Impairment with fMRI-Guided Transcranial Magnetic Stimulation
Cereb Cortex, September 1, 2008; 18(9): 2077 - 2085.
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