Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bellion, A.
Right arrow Articles by Métin, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bellion, A.
Right arrow Articles by Métin, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 13, No. 2, 203-214, February 2003
© 2003 Oxford University Press

Early Differences in Axonal Outgrowth, Cell Migration and GABAergic Differentiation Properties between the Dorsal and Lateral Cortex

Arnaud Bellion, Marion Wassef and Christine Métin

Ecole Normale Supérieure, CNRS UMR 8542, Equipe Régionalisation Nerveuse, 46 Rue d’Ulm, 75230 Paris Cedex 05, France

Address correspondence to Christine Métin, Ecole Normale Supérieure, CNRS UMR 8542, Equipe Régionalisation Nerveuse, 46 Rue d’Ulm 75230 Paris Cedex 05, France. Email: metin{at}biologie.ens.fr.

The regionalization of the cerebral cortex proceeds gradually from early embryonic stages under the control of transcription factors that are expressed in gradients. Two phases can be distinguished at the beginning of cortical development: the genesis of a precocious and transient structure, the preplate, which is followed by development of the cortical plate within the preplate. Cellular indices of early regionalization have not yet been described either in the preplate or in the early cortical plate. In the present study, we identify two regions, lateral and dorsal, in the mouse cortex embryo, which differ strongly in the functional properties of their early neurons. By using culture experiments and grafts on organotypic slices, we show that the earliest neurons in the dorsal cortex extend axons before and more rapidly than the earliest neurons in the lateral cortex. In contrast to the lateral cortex, the dorsal cortex differentiates neurons migrating along axons in vitro. These cells express markers of the GABAergic lineage. Early differences between the two regions suggest that the dorsal part of the cortex generates early neurons with particular intrinsic properties that may in turn specifically influence the later development of the cortical plate in this domain.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
R. L. M. Lett, W. Wang, and T. P. O'Connor
Semaphorin 5B Is a Novel Inhibitory Cue for Corticofugal Axons
Cereb Cortex, October 8, 2008; (2008) bhn179v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Fogarty, M. Grist, D. Gelman, O. Marin, V. Pachnis, and N. Kessaris
Spatial Genetic Patterning of the Embryonic Neuroepithelium Generates GABAergic Interneuron Diversity in the Adult Cortex
J. Neurosci., October 10, 2007; 27(41): 10935 - 10946.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Metin, C. Alvarez, D. Moudoux, T. Vitalis, C. Pieau, and Z. Molnar
Conserved pattern of tangential neuronal migration during forebrain development
Development, August 1, 2007; 134(15): 2815 - 2827.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
L. Zhou, Y. Jossin, and A. M. Goffinet
Identification of Small Molecules That Interfere with Radial Neuronal Migration and Early Cortical Plate Development
Cereb Cortex, January 1, 2007; 17(1): 211 - 220.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. S. O'Connor, S. T. Mills, K. A. Jones, S. N. Ho, and G. K. Pavlath
A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis
J. Cell Sci., January 1, 2007; 120(1): 149 - 159.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Vergano-Vera, M. J. Yusta-Boyo, F. de Castro, A. Bernad, F. de Pablo, and C. Vicario-Abejon
Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells
Development, November 1, 2006; 133(21): 4367 - 4379.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Bellion, J.-P. Baudoin, C. Alvarez, M. Bornens, and C. Metin
Nucleokinesis in Tangentially Migrating Neurons Comprises Two Alternating Phases: Forward Migration of the Golgi/Centrosome Associated with Centrosome Splitting and Myosin Contraction at the Rear
J. Neurosci., June 15, 2005; 25(24): 5691 - 5699.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
C. Wonders and S. A. Anderson
Cortical Interneurons and Their Origins
Neuroscientist, June 1, 2005; 11(3): 199 - 205.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
Q. Xu, I. Cobos, E. De La Cruz, J. L. Rubenstein, and S. A. Anderson
Origins of Cortical Interneuron Subtypes
J. Neurosci., March 17, 2004; 24(11): 2612 - 2622.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.