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Cerebral Cortex, Vol. 12, No. 7, 702-709, July 2002
© 2002 Oxford University Press

Distinct Origins of Neocortical Projection Neurons and Interneurons In Vivo

Stewart A. Anderson,2, Christine E. Kaznowski1, Carrie Horn, John L.R. Rubenstein and Susan K. McConnell1

Department of Psychiatry, University of California at San Francisco, San Francisco and , 1 Department of Biological Sciences, Stanford University, Stanford, CA, USA

Stewart A. Anderson, Department of Psychiatry, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Box 244, Room 929A Lasdon, 1300 York Ave, New York, NY 10021, USA. Email: SAA2007{at}med.cornell.edu.

Recent studies in rodents have suggested that some cortical GABAergic interneurons arise within the neuroepithelium of the subcortical telencephalon then migrate dorsally into the cerebral cortex. These studies have relied heavily on short-term organotypic culture methods and on the analysis of mutant mice that die during the neonatal period. The purpose of this study is to ascertain directly whether cells labeled in the subcortical telencephalon in vivo differentiate into mature cortical interneurons and whether any cortical interneurons arise from the dorsal, cortical neuroepithelium. Mitotic cells within the neonatal cortex or subcortical telencephalon were labeled by focal injections of [3H]thymidine into the brains of neonatal ferrets. The fates of labeled cells were assessed in mature animals 6 weeks later. Our results suggest that many cortical interneurons, but not cortical projection neurons, derive from the subcortical telencephalon. Conversely, cortical projection neurons, but few if any interneurons, are generated within the proliferative zones of the neocortex.


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